A technique developed by Ulrich Zimmermann in which cells are exposed to a low-level, high-frequency electric field that orients them into chains. A direct current pulse is then used to open micropores in adjoining cell membranes. These micropores allow mixing of the cytoplasms, and the cells may eventually fuse. The Zimmermann technique may also alter the permeability of the plasmalemma so that DNA fragments the size of genes can enter the cell.
Subjects: Genetics and Genomics.