Proteins possessing tandemly repeating segments that bind zinc atoms. Each segment contains two closely spaced cysteine molecules followed by two histidines. Each segment folds upon itself to form a fingerlike projection. The zinc atom is linked to the cysteines and histidines at the base of each loop as shown here, where C circles represent cysteine molecules, H circles represent histidine molecules, and unlabeled circles represent the other amino acids of the polypeptide finger. The zinc fingers serve in some way to enable the proteins to bind to DNA molecules, where they regulate transcription. See Chronology, 1985, Miller et al.; 1987, Page et al.; androgen receptor (AR), motifs, transcription factors, vitamin D receptor (VDR), Wilms tumor.
Subjects: Genetics and Genomics.