A cytosolic, homodimeric, zinc-binding enzyme (EC 18.104.22.168, 408 aa) involved in the hydrolysis of most N-acylated or N-acetylated amino acids, possibly a salvage mechanism. Expression of the gene is reportedly reduced or undetectable in small-cell lung carcinoma lines and tumours. Aminoacylase-1 deficiency causes a metabolic disorder in which there is encephalopathy, psychomotor delay, muscular hypotonia and frequent epileptic seizures. Aspartoacylase (EC 22.214.171.124, aminoacylase-2, 313 aa) hydrolyses N-acetyl-l-aspartic acid and deficiency leads to Canavan's disease.
Subjects: Medicine and Health — Chemistry.