AP endonuclease

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'AP endonuclease' can also refer to...

AP endonuclease

AP endonuclease

AP endonuclease

Deletion analysis of human AP-endonuclease: minimum sequence required for the endonuclease activity.

AP endonuclease deficiency results in extreme sensitivity to thymidine deprivation

AP endonuclease independent repair of abasic sites in Schizosaccharomyces pombe

Human AP endonuclease suppresses DNA mismatch repair activity leading to microsatellite instability

AP endonucleases process 5-methylcytosine excision intermediates during active DNA demethylation in Arabidopsis

AP endonuclease knockdown enhances methyl methanesulfonate hypersensitivity of DNA polymerase β knockout mouse embryonic fibroblasts

Untwisting of the DNA helix stimulates the endonuclease activity of Bacillus subtilis Nth at AP sites

Characterization of uracil-DNA glycosylase activity from Trypanosoma cruzi and its stimulation by AP endonuclease

Identification and characterization of mitochondrial abasic (AP)-endonuclease in mammalian cells

Characterisation of new substrate specificities of Escherichia coli and Saccharomyces cerevisiae AP endonucleases

Human AP endonuclease suppresses DNA mismatch repair activity leading to microsatellite instability

The major human AP endonuclease (Ape1) is involved in the nucleotide incision repair pathway

Shape-selective recognition of DNA abasic sites by metallohelices: inhibition of human AP endonuclease 1

AP endonuclease 1 prevents trinucleotide repeat expansion via a novel mechanism during base excision repair

Human AP endonuclease inefficiently removes abasic sites within G4 structures compared to duplex DNA

Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoter


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Quick Reference

Any enzyme that cleaves DNA on the 5′ side of a site in a DNA molecule that lacks a purine or pyrimidine. An AP site is a “hole” in a double-stranded DNA left by removal of a base, but leaving the sugar phosphate backbone intact. AP is the abbreviation for apurinic or apyrimidinic, referring to the loss of purines or pyrimidines. AP sites result when DNA glycosylases (q.v.) remove chemically altered bases from the polymer. An AP endonuclease will then break the phosphodiester backbone, and this allows excision of the damaged region. See cut-and-patch repair.

Subjects: Chemistry — Genetics and Genomics.

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