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5-azacytidine


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5-azacytidine

5-azacytidine

Molecular analysis of 5-azacytidine-induced variants in mammalian cells

Growth and differentiation of rat bone marrow stromal cells: does 5-azacytidine trigger their cardiomyogenic differentiation?

Epigenetic control of early flowering in flax lines induced by 5-azacytidine applied to germinating seed

Somatic Excision of the Ac Transposable Element in Transgenic Arabidopsis thaliana after 5-Azacytidine Treatment

Mechanism of in vivo sister-chromatid exchange induction by 5-azacytidine

Sequence of centromere separation: effect of 5-azacytidine-induced epigenetic alteration

Comparison of transformation by manganese sulfate and 5-azacytidine in Rat 6 cells overexpressing the c-myc oncogene

PCM-10PLASMA AND CEREBROSPINAL FLUID PHARMACOKINETICS OF 5-AZACYTIDINE FOLLOWING INTRAVENOUS, INTRANASAL, AND INTRATHECAL ADMINISTRATION IN A NON-HUMAN PRIMATE MODEL

Frequencies of occurence of all human chromosomes in micronuclei from normal and 5-azacytidine-treated lymphocytes as revealed by chromosome painting

462 Autologous 5-azacytidine-cultured bone-marrow stem cells in surgical treatment of heart failure

EXTH-02. PLASMA AND CEREBROSPINAL FLUID PHARMACOKINETICS OF 5-AZACYTIDINE ALONE AND IN COMBINATION WITH INULIN IN A NON-HUMAN PRIMATE MODEL

Dynamic changes in methylome and transcriptome patterns in response to methyltransferase inhibitor 5-azacytidine treatment in citrus

2′-Deoxyriboguanylurea, the primary breakdown product of 5-aza-2′-deoxyribocytidine, is a mutagen, an epimutagen, an inhibitor of DNA methyltransferases and an inducer of 5-azacytidine-type fragile sites

 

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An analog of cytidine in which a nitrogen atom is substituted for a carbon in the number 5 position of cytosine (q.v.). The analog is incorporated into newly synthesized DNA, and such DNA is undermethylated. Since a reduction in the number of methyl groups attached to genes is associated with an increase in their transcriptional activities, 5-azacytidine can switch on certain genes. For example, patients given the drug may start making fetal hemoglobin, which implies that their gamma genes have been switched on. See hemoglobin, hemoglobin genes.

Subjects: Genetics and Genomics.


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