Overview

cell-driven viral transformation


'cell-driven viral transformation' can also refer to...

 

More Like This

Show all results sharing this subject:

  • Genetics and Genomics

GO

Show Summary Details

Quick Reference

A method for creating immortalized human antibody-producing cells in vitro without forming a hybridoma (q.v.). Normal B lymphocytes from an immunized donor are mixed with other cells infected with the Epstein-Barr virus (q.v.). The virus enters the B lymphocytes. The cells originally infected with the virus are experimentally destroyed, and the virally transformed cells producing the antibody of interest are isolated. In cell-driven viral transformation, about 1 in 50 B lymphocytes is transformed, whereas with the cell hybridization technique only about 1 human cell in 10 million is transformed.

Subjects: Genetics and Genomics.


Reference entries

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.