chromatin silencing

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'chromatin silencing' can also refer to...

chromatin silencing

chromatin silencing

The impact of chromatin in human cancer: linking DNA methylation to gene silencing

Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway?

Local and regional chromatin silencing in Candida glabrata: consequences for adhesion and the response to stress

Silencing subtelomeric VSGs by Trypanosoma brucei RAP1 at the insect stage involves chromatin structure changes

Repeat-associated siRNAs cause chromatin silencing of retrotransposons in the Drosophila melanogaster germline

Polycomb Group-Dependent, Heterochromatin Protein 1-Independent, Chromatin Structures Silence Retrotransposons in Somatic Tissues Outside Ovaries

Silencing of multi-copy HPV16 by viral self-methylation and chromatin occlusion: a model for epigenetic virus–host interaction

CITED2 silencing sensitizes cancer cells to cisplatin by inhibiting p53 trans-activation and chromatin relaxation on the ERCC1 DNA repair gene

Silenced yeast chromatin is maintained by Sir2 in preference to permitting histone acetylations for efficient NER

Selective requirement of H2B N-Terminal tail for p14ARF-induced chromatin silencing

Heterogeneity in the modification and involvement of chromatin components of the CpG island of the silenced human CDH1 gene in cancer cells

Altered chromatin structure associated with methylation-induced gene silencing in cancer cells: correlation of accessibility, methylation, MeCP2 binding and acetylation

A minimal ubiquitous chromatin opening element (UCOE) effectively prevents silencing of juxtaposed heterologous promoters by epigenetic remodeling in multipotent and pluripotent stem cells

Susceptibility allele-specific loss of miR-1324-mediated silencing of the INO80B chromatin-assembly complex gene in pre-eclampsia

Aberrant de novo methylation of the p16 INK4A CpG island is initiated post gene silencing in association with chromatin remodelling and mimics nucleosome positioning


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The inactivation of gene transcription as a result of condensation of chromosomal DNA into heterochromatin (see chromatin). A key mechanism for maintaining DNA in a silent state is chemical modification of the histone proteins that form the scaffolding around which the DNA is coiled. Methylation of certain amino acids in the ‘tails’ of the histones, which protrude from the coiled chromatin structure, is associated with silencing of genes, whereas acetylation tends to activate gene transcription. Chromatin-binding proteins, such as heterochromatin protein 1 (HP1), bind to the methylated histones and reinforce the silenced state by recruiting histone methyltransferases, which add more methyl groups to the histones. It is now known that small RNA molecules are also involved in chromatin silencing, for example in inactivation of one or more X chromosomes in female mammals (see X inactivation).

Subjects: Biological Sciences.

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