A multiprotein complex (DPC, costamere) that links the actin cytoskeleton with extracellular matrix. According to the tissue, syntrophin, dystrobrevin, sarcoglycan, and dystroglycan isoforms are involved and defects in any of the components of the chain can cause disease. In muscle, defects lead to muscular dystrophies (see also dystrophin). The role of the complex may be to cluster and anchor signalling proteins and ion and water channels.
Subjects: Medicine and Health.