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A transcription elongation factor, which increases the overall rate at which RNA polymerase II transcribes duplex DNA, first identified in mammalian systems, and composed of three subunits, elongin A, B, and C. Elongin A (transcription elongation factor B; 772 aa) is the active subunit of the elongin complex, an F-box protein. Elongins B (118 aa) and C (112 aa) are regulatory subunits which form a stable binary complex that interacts with elongin A and strongly induces its transcriptional activity. Elongin C has homology to Skp1. The von Hippel–Lindau (VHL) tumour suppressor protein will bind the elongin BC complex preventing it from activating elongin A.

Subjects: Medicine and Health — Chemistry.

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