Escherichia coli haemolysins

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A family of membrane-permeabilizing exotoxins (~303 aa) of the RTX family produced by many E. coli strains that are responsible for nonintestinal infections. Lytic activity depends on binding of calcium ions to the toxin in solution, causing a conformational change and allowing it to produce a functional pore when it binds to membranes.

Subjects: Medicine and Health.

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