A rather general term for developmentally regulated polypeptides from neural tissues. More specifically GAP-43 (neuromodulin) is an acidic membrane phosphoprotein that regulates neural cell adhesion molecule (NCAM)-mediated neurite outgrowth. It is a substrate for protein kinase C (originally identified as pp46) and is now known to be identical to B-50 that regulates phosphotidylinositol turnover in mature presynaptic membranes and F1 found in the hippocampus during long-term potentiation. It is not restricted to neurons but is also found in astrocytes. Another member of the family, also involved in regulating neurite outgrowth, is brain acid-soluble protein (BASP1), also known as CAP-23; the rat homologue is the 22-kDa neuronal tissue-enriched acidic protein, NAP-22. BASP1 is also present in significant amounts in kidney, testis, and lymphoid tissues.
Subjects: Medicine and Health.