Excessive plasma acidity due to an accumulation of lactic acid. This may be caused by a variety of illnesses, including heart failure or severe dehydration. It can also be caused by the accumulation of biguanide drugs used for treating type 2 diabetes mellitus, particularly when kidney failure is present. Biguanides (see metformin) should therefore not be used to treat patients who also have kidney disease or heart failure or who are dehydrated.
Subjects: Medicine and Health.