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Transmembrane GTPases, (mitofusin-1, 741 aa; mitofusin-2, 757 aa) which mediate mitochondrial fusion independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks. Mitofusin-2 is important in regulating proliferation of vascular smooth muscle cells and defects in mitofusin-2 cause Charcot–Marie–Tooth disease type 2A2.

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