Overview

nectin


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1. A protein component of the stalk of mitochondrial ATPase.

2. An immunoglobulin-like cell adhesion molecule that is calcium-independent and causes adhesion by interaction with other nectin molecules. The cytoplasmic domain interacts with afadin and, in conjunction with the cadherin–*catenin system, is important in organizing adherens junctions. Nectins are receptors for various viruses, including poliovirus. Mutation in the gene for nectin 1 (poliovirus receptor-like 1) is responsible for cleft lip/palate–ectodermal dysplasia syndrome. Nectin-like protein 1 is synCAM 3.

Subjects: Medicine and Health.


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