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otocadherin


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A large single-pass transmembrane protein (cadherin 23, 3354 aa) that is involved, together with protocadherin 15 (PCDH15) in forming the tip links at the tips of stereocilia of the hair cells of the inner ear. These tip links are thought to gate the mechanoelectrical channel that transduces movement into electrical impulse. The extracellular domain contains 27 repeats with significant homology to the cadherin ectodomain, and otocadherin also interacts with harmonin. Mutations in otocadherin are involved in Usher's syndrome (type 1D).

Subjects: Medicine and Health.


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