prolyl hydroxylase

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prolyl hydroxylase

prolyl hydroxylase

Prolyl 4-hydroxylase genes are subjected to alternative splicing in roots of maize seedlings under waterlogging

Inhibition of prolyl 4-hydroxylase prevents left ventricular remodelling in rats with thoracic aortic banding

Deficiency of the oxygen sensor prolyl hydroxylase 1 attenuates hypercholesterolaemia, atherosclerosis, and hyperglycaemia

Preconditioned suppression of prolyl-hydroxylases attenuates renal injury but increases mortality in septic murine models

Prolyl 3-hydroxylase 1 and CRTAP are mutually stabilizing in the endoplasmic reticulum collagen prolyl 3-hydroxylation complex

Silencing of HIF Prolyl-Hydroxylase 2 Gene in the Renal Medulla Attenuates Salt-Sensitive Hypertension in Dahl S Rats

The good, the bad and the ugly in oxygen-sensing: ROS, cytochromes and prolyl-hydroxylases

Prolyl-4-hydroxylase-α1 improves the stability of advanced plaques but accelerates the atherosclerotic lesion formation of early plaques

P020 Silencing of prolyl hydroxylase 1 in intestinal microvascular endothelial cells prevents inflammation-induced endothelial dysfunction and dampens murine colitis

Prolyl-hydroxylase inhibitor activating hypoxia-inducible transcription factors reduce levels of transplant arteriosclerosis in a murine aortic allograft model

P088 Differential expression of prolyl hydroxylases 1 and 3 between IBD and non-IBD patients

The protective effect of prolyl-hydroxylase inhibition against renal ischaemia requires application prior to ischaemia but is superior to EPO treatment

Inhibition of prolyl 4-hydroxylase, beta polypeptide (P4HB) attenuates temozolomide resistance in malignant glioma via the endoplasmic reticulum stress response (ERSR) pathways

Hypoxia inducible factor prolyl hydroxylase 2 (PHD2) is a direct regulator of epidermal growth factor receptor (EGFR) signaling in breast cancer

Phase 2 studies of oral hypoxia-inducible factor prolyl hydroxylase inhibitor FG-4592 for treatment of anemia in China

Differential and Reciprocal Regulation between Hypoxia-inducible Factor-α Subunits and their Prolyl Hydroxylases in Pulmonary Arteries of Rat with Hypoxia-induced Hypertension

Src activates HIF-1α not through direct phosphorylation of HIF-1α-specific prolyl-4 hydroxylase 2 but through activation of the NADPH oxidase/Rac pathway


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The enzyme (EC, 534 aa) that hydroxylates proline to hydroxyproline in procollagen. It is a heterotetramer of two α2 chains and two β chains; the active site has a ferrous ion, and a reducing agent such as ascorbate is necessary as a cofactor.

Subjects: Medicine and Health.

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