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1. The serpin–enzyme complex, formed by a serpin and a serine peptidase. The SEC receptor is expressed on hepatocytes and binds to a conserved sequence in α1-antitrypsin and other serpins. It mediates catabolism of the complex and stimulates serpin production.

2. Selenocysteine (Sec).

3. Size-exclusion chromatography (SEC).

4. The general secretory (sec) pathway in bacteria.

5. sec proteins (often with a numerical suffix, e.g. Sec 7, sec65) are involved in the secretory pathway for proteins.

6. sec61 is a channel (translocon) that allows movement of proteins across cellular membranes and integrates transmembrane proteins into lipid bilayers. (It is homologous to the SecY channel in bacteria and archaea.) The channel is a heterotrimeric complex (α, β, and γ) that associates with the subcomplex Sec62/Sec63 and interacts with the signal peptidase complex.

Subjects: Medicine and Health.

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