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A small RNA molecule that is a component of most ribosomes. The 5S rRNA molecule shown in the illustration is from E. coli. 5S rRNA occurs in the large ribosomal subunit in the cytosol of all prokaryotes and eukaryotes. While the molecule stabilizes the structure of the large ribosomal subunit, 5S rRNA does not contribute directly to any of the active sites in the subunit. 5S rRNA occurs in the ribosomes of the mitochondria of plants and in the ribosomes of their chloroplasts. However, the ribosomes of the mitochondria of fungi and animals lack 5S rRNAs. In humans, the 5S rRNA locus is near the telomere of the short arm of chromosome 1. In Drosophila melanogaster, it is on 2R at 56 E-F. See Chronology, 1963, Rosset and Monier; 1970, Wimber and Steffensen; 1973, Ford and Southern; 1985, Miller, McLachlan, and Klug; Drosophila salivary gland chromosomes, ribosomal RNA genes, ribosome, RNA polymerase, Xenopus.

5S rRNA. From P. B. Moore, Chapter 10, Fig. 3C, in Ribosomal RNA: Structure, Evolution, Processing and Function in Protein Biosynthesis, R. A. Zimmermann and A. E. Dahlberg (eds.), 1996. CRC Press, Florida.

Subjects: Genetics and Genomics.

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