1 The condition in which a gene occurs at 100% frequency in a population; i.e. there is no polymorphism, all members of a population being homozygous for a particular allele at a given locus.
2 The first step in making permanent preparations of tissues for microscopic study, by killing cells and preventing subsequent decay with as little distortion of structure as possible. Examples of fixatives are formaldehyde and osmium tetroxide, often used as mixtures.
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