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A protein (DNA crosslink repair protein 1C, 685 aa) with single-strand-specific 5′-to-3′ exonuclease activity regulated by DNA-dependent protein kinase and involved in V(D)J recombination in the immune system and in DNA repair. Mutation can lead to a form of severe combined immunodeficiency syndrome that is complicated by radiation sensitivity.

Subjects: Medicine and Health.

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