Preclinical Approaches to Understanding Anxiety Disorders

Victoria B. Risbrough and Mark A. Geyer

in Oxford Handbook of Anxiety and Related Disorders

Published in print September 2008 | ISBN: 9780195307030
Published online September 2012 | | DOI:

Series: Oxford Library of Psychology

Preclinical Approaches to Understanding Anxiety Disorders

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  • Psychology
  • Clinical Psychology



This chapter reviews rodent tests most commonly used to screen experimental manipulations (e.g., pharmacological, genetic mutation) on murine anxiety-like behavior, and highlight recent strategies for examining basic systems related to anxiety and stress (e.g., glyoxalase 1, corticotropin releasing factor, serotonin, and stathmin). The animal models described in this chapter (e.g., fear-potentiated startle, conditioned fear, and approach/avoidance conflict tests) have been instrumental to examine the physiological underpinnings of state anxiety and fear, develop anxiolytic compounds, and, more recently, to understand genetic and environmental influences on “trait” anxiety.

Keywords: animal model; anxiety; fear; mutation; stress; startle

Article.  9470 words. 

Subjects: Psychology ; Clinical Psychology

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