Article

Neuroanatomy and Neuroimaging of Anxiety Disorders

Jennifer C. Britton and Scott L. Rauch

in Oxford Handbook of Anxiety and Related Disorders

Published in print September 2008 | ISBN: 9780195307030
Published online September 2012 | | DOI: http://dx.doi.org/10.1093/oxfordhb/9780195307030.013.0009

Series: Oxford Library of Psychology

Neuroanatomy and Neuroimaging of Anxiety Disorders

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Neuroimaging methods can be used to examine functional brain differences between healthy individuals and those with anxiety disorders. After the brain regions implicated in the pathophysiology of anxiety disorders (e.g., amygdalo-cortical circuitry) are reviewed, neuroimaging studies of posttraumatic stress disorder (PTSD), social anxiety disorder (SAD), specific phobia (SP), and panic disorder (PD) that report activations in these regions are discussed. Studies of obsessive-compulsive disorder (OCD) implicate a distinct neurocircuitry profile (i.e., cortico-striatal-thalamic circuit) compared to the other anxiety disorders. Few neuroimaging studies of generalized anxiety disorder (GAD) have been conducted. In addition, results from functional connectivity analyses and the effects of treatment on neuroimaging findings are summarized.

Keywords: amygdala; cingulate; fMRI; hippocampus; insula; medial prefrontal cortex; neuroanatomy; neurocircuitry; neuroimaging

Article.  9630 words. 

Subjects: Psychology ; Clinical Psychology

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