Article

Social Regulation of Gene Expression in the Immune System

Steven W. Cole

in The Oxford Handbook of Psychoneuroimmunology

Published in print July 2012 | ISBN: 9780195394399
Published online November 2012 | | DOI: http://dx.doi.org/10.1093/oxfordhb/9780195394399.013.0014

Series: Oxford Library of Psychology

 Social Regulation of Gene Expression in the Immune System

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Social factors influence health in part by altering the expression of genes in diseased tissue and immune cells. This chapter surveys the emerging field of social genomics, which has begun to identify the types of genes subject to social regulation, the biological signaling pathways mediating those effects, and the genetic polymorphisms that moderate socioenvironmental influences on human gene expression. After highlighting the implications of these dynamics for immune response and host defense, this chapter considers the evolutionary basis for the deep functional connections between social behavior and immune response.

Keywords: genetics; genomics; social factors; gene-environment interactions

Article.  13809 words. 

Subjects: Psychology ; Health Psychology ; Social Psychology

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