Article

Psychoneuroimmunology of Fatigue and Sleep Disturbance: The Role of Pro-inflammatory Cytokines

Shamini Jain, Julienne Bower and Michael R. Irwin

in The Oxford Handbook of Psychoneuroimmunology

Published in print July 2012 | ISBN: 9780195394399
Published online November 2012 | | DOI: http://dx.doi.org/10.1093/oxfordhb/9780195394399.013.0018

Series: Oxford Library of Psychology

 Psychoneuroimmunology of Fatigue and Sleep Disturbance: The Role of Pro-inflammatory Cytokines

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Fatigue and sleep disturbance are rampant in today's society and bear significant costs in terms of health-care dollars, productivity, social relationships, and individual quality of life. Fatigue and sleep disturbance often co-occur in relatively healthy populations as well as in several clinical populations. This chapter discusses the psychoneuroimmunological underpinnings of fatigue and sleep disturbance, focusing specifically on the role of pro-inflammatory cytokines as contributors to both fatigue and sleep problems. The chapter provides a basic review of fatigue and sleep, as well as neuro-immune processes underlying these behaviors. Perpetuating factors, treatment approaches, and future research directions are also discussed.

Keywords: fatigue; sleep; sleepiness; sickness behavior; inflammation; HPA

Article.  15073 words. 

Subjects: Psychology ; Health Psychology ; Social Psychology

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