Psychoneuroimmunology and Cancer: Biobehavioral Influences on Tumor Progression

Susan K. Lutgendorf, Erin S. Costanzo and Anil K. Sood

in The Oxford Handbook of Psychoneuroimmunology

Published in print July 2012 | ISBN: 9780195394399
Published online November 2012 | | DOI:

Series: Oxford Library of Psychology

 Psychoneuroimmunology and Cancer: Biobehavioral Influences on Tumor Progression

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This chapter examines the role of psychosocial factors and stress-related neuroendocrine hormones in cancer progression. The neuroendocrine stress response appears to play a key role in modulating physiological pathways relevant to cancer progression. These include tumor angiogenesis, invasion, anoikis, inflammation, the cellular immune response, and various cell-signaling pathways. These stress-response pathways also potentially interact with cancer treatments. Bidirectional influences of tumor-derived cytokines and other molecules on the hypothalamic pituitary adrenal (HPA) axis and CNS processes are also discussed along with implications for disease progression and survival. These mechanisms point to emerging possibilities for psychosocial, pharmacological, and integrative medicine interventions that have the potential to alter stress-response signaling pathways in cancer.

Keywords: cancer; stress; depression; immunity; inflammation; angiogenesis; invasion; psychoneuroimmunology

Article.  22284 words. 

Subjects: Psychology ; Health Psychology ; Social Psychology

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