The size of motor-evoked potentials: influencing parameters and quantification

Kai M. Rösler and Michel R. Magistris

in Oxford Handbook of Transcranial Stimulation

Published in print January 2008 | ISBN: 9780198568926
Published online November 2012 | e-ISBN: 9780191744013 | DOI:

Series: Oxford Library of Psychology

 The size of motor-evoked potentials: influencing parameters and quantification

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This article discusses parameters influencing the size of motor-evoked potentials (MEPs) in normal and pathological conditions, and the methods of meaningful quantification of the MEPs. MEPs are widely used to study the physiology of corticospinal conduction in healthy subjects and in patients with diseases of the central nervous system. The characteristics of MEP size are, stimulus intensity, coil positioning, and facilitation. MEPs show variability in size and shape from one stimulus to the next, even if the stimulus parameters are kept constant. This article describes the triple stimulation technique (TST), which was developed to eliminate the effects of phase cancellation from the MEPs, to allow for a better quantification. Pathological conditions may modify the parameters discussed in the article and influence the size of the MEPs by lesions of motor neurons or of their axons, central conduction velocity slowing, or conduction block.

Keywords: motor-evoked potentials; pathological conditions; corticospinal conduction; triple stimulation technique; quantification; pathological conditions

Article.  7505 words. 

Subjects: Neuropsychology ; Cognitive Neuroscience

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