Article

Methodological issues in clinical trial design for TMS

Mark A. Demitrack and Sarah H. Lisanby

in Oxford Handbook of Transcranial Stimulation

Published in print January 2008 | ISBN: 9780198568926
Published online November 2012 | | DOI: http://dx.doi.org/10.1093/oxfordhb/9780198568926.013.0039

Series: Oxford Library of Psychology

 Methodological issues in clinical trial design for TMS

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This article explores the emergence of transcranial magnetic stimulation (TMS) as a new therapeutic approach and the implications of this technology for the study and treatment of neuropsychiatric disorders, with a focus on major depression. Relapse, chronicity, and varying degrees of treatment resistance characterize major depression. A substantial number of patients are not effectively treated with pharmacology or medications alone. It is proposed that TMS, along with other device-based therapies emerging in psychiatry, may define a potential new treatment platform, with existing therapeutics for major depression. Through the example of a study, this article describes the methodological considerations in the development of TMS for the treatment of major depression. Device-based approaches to therapeutic neuromodulation hold the promise of significant clinical advantages compared to existing treatments for major depression, but evidence in well designed and properly blinded multicenter trials is still lacking, hence, research in this area is ongoing.

Keywords: therapeutic; neuropsychiatric disorders; major depression; neuromodulation; transcranial magnetic stimulation; treatment

Article.  6176 words. 

Subjects: Psychology ; Neuropsychology ; Cognitive Neuroscience

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