TMS clinical trials involving patients with schizophrenia

Ralph E. Hoffman and Arielle D. Stanford

in Oxford Handbook of Transcranial Stimulation

Published in print January 2008 | ISBN: 9780198568926
Published online November 2012 | | DOI:

Series: Oxford Library of Psychology

TMS clinical trials involving patients with schizophrenia

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  • Psychology
  • Neuropsychology
  • Cognitive Neuroscience



Repetitive transcranial magnetic stimulation ((r)TMS) is being studied as an experimental intervention for patients with neuropsychiatric disorders. These approaches have been informed by animal studies of long-term potentiation (LTP) and long-term depression (LTD). They show that repeated stimulation of neural circuits could exert effects on synaptic efficacy, for varying amounts of time, beyond the period of stimulation. Few studies using rTMS as a potential clinical intervention for schizophrenia have been carried out. They show promise in terms of advancing the understanding of pathophysiological mechanisms and developing alternative interventions. These studies, considered together, suggest that rTMS holds promise as an intervention strategy for patients with schizophrenia. Rigorously designed trials with larger numbers of subjects are indicated in order to take into account nonspecific factors that could add noise to outcome data.

Keywords: long-term potentiation; long-term depression; neuropsychiatric disorders; synaptic efficacy; schizophrenia; stimulation

Article.  8854 words. 

Subjects: Psychology ; Neuropsychology ; Cognitive Neuroscience

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