Journal Article

Evolution of the Apolipoprotein E Receptor 2 Gene by Exon Loss

Hyoun-Ju Kim, Dong-Ho Kim, Kenta Magoori, Shigeru Saeki and Tokuo T. Yamamoto

in The Journal of Biochemistry

Published on behalf of The Japanese Biochemical Society

Volume 124, issue 2, pages 451-456
Published in print August 1998 | ISSN: 0021-924X
Published online August 1998 | e-ISSN: 1756-2651 | DOI:
Evolution of the Apolipoprotein E Receptor 2 Gene by Exon Loss

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The apolipoprotein E receptor 2 (apoER2) gene consists of a mosaic of exons, which may have been assembled by “exon shuffling.” Analysis of apoER2 transcripts in several species reveals a lost repeat in the ligand-binding domain of primate apoER2. A pseudo-exon found in the primate apoER2 genes corresponds to the lost repeat but contains a crucial deletion that leads to a translational frameshift. The pseudo-exon sequence in primary transcripts of the human apoER2 gene is shown to be abolished by exon skipping due to two nucleotide substitutions at the 5'-splice donor adjacent to the pseudo-exon. These data suggest the occurrence of exon loss in the evolution of the primate apoER2 gene.

Keywords: apoE receptor; exon shuffling; exon skipping; pseudo exon; repetitive sequence

Journal Article.  0 words. 

Subjects: Biochemistry

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