Journal Article

Circulating Parathyroid Hormone-related Protein (109–141) in Malignancy-associated Hypercalcemia

Koichi Nagasaki, Kotomi Otsubo, Naoko Kajimura, Rie Tanaka, Hiroshi Watanabe, Yuji Tachimori, Hoichi Kato, Hajime Yamaguchi, Daizo Saito, Toru Watanabe, Isamu Adachi and Ken Yamaguchi

in Japanese Journal of Clinical Oncology

Volume 26, issue 1, pages 6-11
Published in print February 1996 | ISSN: 0368-2811
e-ISSN: 1465-3621 | DOI:
Circulating Parathyroid Hormone-related Protein (109–141) in Malignancy-associated Hypercalcemia

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For differential diagnosis between hypercalcemia-induced bone metastasis and humoral hypercalcemia of malignancy (HHM), serum parathyroid hormone-related protein (PTHrP) concentrations were measured in normal subjects and patients with malignancy-associated hypercalcemia according to the presence or absence of bone metastasis, using a new sensitive PTHrP(109–141) radioimmunoassay system. The serum PTHrP(109–141) levels in all of 14 patients without bone metastasis were significantly higher than those in normal subjects. However, in four patients with hypercalcemia associated with bone metastasis the levels were nearly the same as those in normal subjects. The time course in two hypercalcemic patients with esophageal carcinoma revealed that serum PTHrP(109–141) levels were elevated before hypercalcemia developed and that changes in PTHrP(109–141) and corrected serum calcium levels were significantly correlated. These findings suggest that determination of serum PTHrP(109–141) may be clinically important not only for differential diagnosis of HHM but also as a useful predictive marker of hypercalcemia.

Keywords: Hypercalcemia; Parathyroid hormone-related protein; Paraneoplastic syndrome; Tumor marker; Esophageal carcinoma

Journal Article.  0 words. 

Subjects: Medical Oncology

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