Journal Article

Dense deposit disease in association with monoclonal gammopathy of unknown significance

F. Sepandj and A. Trillo

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 11, issue 11, pages 2309-2312
Published in print November 1996 | ISSN: 0931-0509
e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/oxfordjournals.ndt.a027156
Dense deposit disease in association with monoclonal gammopathy of unknown significance

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Several renal pathologic entities have been reported in patients with lymphoplasmacytic disorders with their typical excess immunoglobulin production. We report dense deposit disease in a patient who was discovered to have an IgG kappa monoclonal protein without clinical evidence of underlying lymphoplasma cytic malignancy during investigation for chronic renal failure with associated nephrotic range proteinuria. This case is unusual since dense deposit disease occurs only rarely in older patients and has not been reported in association with monoclonal gammopathy of unknown significance. Because of the diversity of renal lesions associated with lymphoplasmacytic disorders, renal biopsy is necessary to assess the type of renal lesion in this patient population.

Keywords: Dense deposit disease; nephrotic proteinuria; monoclonal gammopathy of unknown significance

Journal Article.  0 words. 

Subjects: Nephrology

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