Journal Article

Elevated plasminogen activator inhibitor levels in cyclosporin-treated renal allograft recipients

G. A. Verpooten, F. J. Cools, M. G. van der Planken, L. C. Bedert, R. Claes, L. F. van Gaal and M. E. de Broe

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 11, issue 2, pages 347-351
Published in print February 1996 | ISSN: 0931-0509
Published online February 1996 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/oxfordjournals.ndt.a027265
Elevated plasminogen activator inhibitor levels in cyclosporin-treated renal allograft recipients

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Atherosclerosis and thrombosis, two major causes of morbidity and mortality in renal transplant recipients, share the same clinical risk factors including decreased fibrinolysis and lipid disturbances. In a crosssectional study we have determined parameters of fibrinolysis in control subjects (n=23) and stable renal allograft recipients without cyclosporin CsA (n=10) and with CsA (n=87) in their immunosuppressive treatment. In CsA-treated patients, tissue-type plasminogen activator was moderately increased compared to patients without CsA (8.4±3.3 vs 5.5±2.8 ng/ml). The plasminogen activator inhibitor (PAI) activity in plasma was clearly increased in CsA-treated patients: 14.5±8.8 vs 7.2±3.2 in normal controls and 8.5±2.4 AU/ml in patients without CsA. Total cholesterol and LDL cholesterol levels were higher in CsA-treated patients (256±62 and 169±60 mg/dl) than in patients without CsA (209±45 and 136±44 mg/dl). The two groups did not differ in HDL cholesterol, triglycerides, and lipoprotein(a). Hypercholesterolaemia, obesity, and steroid-induced diabetes could be identified as risk factors for elevated plasma PAI activity in CsA-treated patients. Hypofibrinolysis induced by elevated PAI levels and increased LDL cholesterol may contribute to the increased thrombogenicity and accelerated atherosclerosis observed in cyclosporin-treated patients.

Keywords: cholesterol; cyclosporin; fibrinolysis; lipids; plasminogen activator inhibitor; renal allograft recipients

Journal Article.  0 words. 

Subjects: Nephrology

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