Journal Article

Retention of an albumin-bound furan dicarboxylic acid in patients with chronic renal failure or after a kidney transplant

M. G. Costigan, M. Yaqoob and W. E. Lindup

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 11, issue 5, pages 803-807
Published in print May 1996 | ISSN: 0931-0509
e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/oxfordjournals.ndt.a027402
Retention of an albumin-bound furan dicarboxylic acid in patients with chronic renal failure or after a kidney transplant

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Background

3-Carboxy-4-methyl-5-propyl-2-furanpropanoic acid (5-propyl FPA) is a furan dicarboxylic acid which accumulates in the plasma of patients with renal impairment. 5-Propyl FPA is an inhibitor of the binding of drugs to albumin and is also implicated in other aspects of the uraemic syndrome.

Methods

Plasma concentrations of propyl FPA have been measured in non-dialysis-dependent, chronic renal failure patients and in renal transplant patients by high-performance liquid chromatography. Concentrations of haemoglobin, albumin and creatinine were also determined.

Results

There was a positive correlation between serum creatinine and 5-propyl FPA and a negative correlation between haemoglobin concentration and 5-propyl FPA in chronic renal failure patients. There was a negative correlation between 5-propyl FPA and duration of transplant only when the serum creatinine was >200 μM. The mean plasma concentration of 5-propyl FPA in chronic renal failure patients with plasma creatinine <200 μM was similar to controls but the mean concentrations were significantly elevated in these patients and also in transplant patients when their plasma creatinine >200 μM. Despite a successful renal transplant the plasma concentration of 5-propyl FPA remained higher than in either controls or in patients with an equivalent degree of renal impairment from miscellaneous causes.

Conclusion

This retention of 5-propyl FPA may therefore reflect a specific tubular defect in renal transplant patients treated with cyclosporin and points to the possibility that 5-propyl FPA may serve as a marker of tubular dysfunction.

Keywords: furan dicarboxylic acid; 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid; chronic renal failure; renal transplant; albumin; protein binding

Journal Article.  0 words. 

Subjects: Nephrology

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