Journal Article

Nosocomial outbreak of <i>Aspergillus fumigatus</i> infection among patients in a renal unit?

A. Sessa, M. Meroni, G. Battini, F. Pitingolo, F. Giordano, M. Marks and P. Casella

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 11, issue 7, pages 1322-1324
Published in print July 1996 | ISSN: 0931-0509
Published online July 1996 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/oxfordjournals.ndt.a027546
Nosocomial outbreak of Aspergillus fumigatus infection among patients in a renal unit?

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Aspergillus fumigatus is present in the environment worldwide and it is only able to infect debilitated or immunodepressed subjects. Nosocomial outbreaks of A. fumigatus infection have been associated with hospital reconstruction. Spores are released into the environment and are inhaled by immunodepressed patients housed in nearby Medical Units. Specific clinical syndromes are allergic bronchopulmonary aspergillosis and invasive pulmonary aspergillosis with characteristic radiological features. Invasive A. fumigatus infection is commonly fatal, even if promptly diagnosed and treated. Three consecutive cases of A. fumigatus infection occurred in debilitated patients housed in our Renal Unit while building renovation near the Unit was being performed. Two of these patients died and pulmonary and diffuse aspergillosis was found on postmortem examination. The third patient, highly suspected to be infected with Aspergillus, was aggressively and successfully treated with liposomal amphotericin B. Our experience suggests that fungal infections have gained increasing prominence in clinical medicine and they must be considered in chronic debilitated patients including dialysis patients, and that liposomal amphotericin B represents an important advance in the treatment of aspergillosis.

Keywords: Aspergillus fuinigatus infection; immunodepression; liposomal amphotericin B

Journal Article.  0 words. 

Subjects: Nephrology

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