Journal Article

Adequacy of haemodialysis and nutrition in maintenance haemodialysis patients: clinical evaluation of a new on-line urea monitor

P. Chauveau, C. Naret, J. Puget, B. Zins and J. L. Poignet

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 11, issue 8, pages 1568-1573
Published in print August 1996 | ISSN: 0931-0509
e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/oxfordjournals.ndt.a027615
Adequacy of haemodialysis and nutrition in maintenance haemodialysis patients: clinical evaluation of a new on-line urea monitor

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Background.

Recent developments in urea sensing monitoring show a good agreement between on-line and direct dialysis quantification which permits evaluation of both effective dialysis efficiency and protein catabolic rate of dialysis patients.

Methods.

Fifty chronic haemodialysis patients were enrolled in a prospective study using an automatic urea sensing monitor operating on spent dialysate (U.M. 1000, Baxter). Dietary protein intake (DPI) and energy intake (DEI) were carefully evaluated by a skilled dietitian over 1 week. During this run U.M. 1000 was used to provide urea mass removed, effective Kt/V and normalized nPCR. Blood samples were drawn pre- and post-dialysis for classical blood-based single pool Kt/V calculations at each session.

Results.

For all patients results were as follows (mean±SD): Effective Kt/V 1.4±0.3, nPCR 1.2±0.3 g/Kg/day, DPI 1.2±0.3 g/Kg/day and DEI 30.1±7.2 Kcal/kg/day; blood-based single pool Kt/V 1.5±0.3. A strong correlation was found between nPCR and DPI for the 50 patients over 1 week (r=0.75, P<0.0001) and between effective Kt/V and single pool calculated Kt/V (r=0.76).

Conclusions.

Urea Monitor 1000 is easy and convenient to use and there was a good correlation of the predialysis BUN and effective Kt/V with standard blood-side measurements. In stable haemodialysis patients who are not strongly catabolic or anabolic, the urea monitor measurement of nPCR correlated with DPI measured by a 7-day dietary record.

Keywords: adequacy of dialysis; dietary protein intake; haemodialysis; nutrition; on-line urea monitor; protein catabolic rate

Journal Article.  0 words. 

Subjects: Nephrology

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