Journal Article

Oxidative Damage to Membranes by a Combination of Aluminum and Iron in Suspension-Cultured Tobacco Cells

Yoko Yamamoto, Akiko Hachiya and Hideaki Matsumoto

in Plant and Cell Physiology

Published on behalf of Japanese Society of Plant Physiologists

Volume 38, issue 12, pages 1333-1339
Published in print January 1997 | ISSN: 0032-0781
Published online January 1997 | e-ISSN: 1471-9053 | DOI: http://dx.doi.org/10.1093/oxfordjournals.pcp.a029126
Oxidative Damage to Membranes by a Combination of Aluminum and Iron in Suspension-Cultured Tobacco Cells

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Aluminum (Al) and ferrous iron [Fe(II)] are separately non-toxic to cultured tobacco cells in nutrient solution. However, Al and Fe(II) together cause the peroxidation of membrane iipids, the accumulation of Al and Fe, and the loss of viability [Ono et al. (1995) Plant Cell Physiol. 36: 115]. We investigated the cause-and-effect relationships of these various responses. In cells exposed to Fe(TT) or Fe(III)-EDTA, both the peroxidation of ipids and the loss of viability were similarly enhanced by AlCl3 in a dose-dependent manner. During exposure to AlCl3, the accumulation of Al and the loss of viability became apparent rapidly and simultaneously at 8 h, whereas both the peroxidation of lipids and the accumulation of Fe occurred at later times. However, lipophilic antioxidants protected cells efficiently not only from the peroxidation of Iipids but also from the loss of viability and the accumulation of Al and Fe. These results suggest that the peroxidation of Iipids in the plasma membrane that is caused by both Al and Fe leads to the accumulation of Al and Fe and the loss of viability.

Keywords: Aluminum; Antioxidants; Iron; Lipid peroxidation; Nicotiana tabacum

Journal Article.  0 words. 

Subjects: Biochemistry ; Molecular and Cell Biology ; Plant Sciences and Forestry

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