Journal Article

Dose-Response Curve for Translocation Frequency with Single Pair of Painted Chromosome. A Comparison with Dicentric and Micronuclei Frequency

P. Venkatachalam, S.F.D. Paul, M.N. Mohankumar, B.K. Prabhu, N. Gajendiran and R.K. Jeevanram

in Radiation Protection Dosimetry

Volume 87, issue 2, pages 101-108
Published in print January 2000 | ISSN: 0144-8420
Published online January 2000 | e-ISSN: 1742-3406 | DOI: https://dx.doi.org/10.1093/oxfordjournals.rpd.a032981
Dose-Response Curve for Translocation Frequency with Single Pair of Painted Chromosome. A Comparison with Dicentric and Micronuclei Frequency

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A translocation dose-response curve using a single pair of painted chromosomes was constructed. The translocation frequencies observed at different doses were compared to those obtained for dicentrics (DC) and micronuclei (MN). The translocation and DC frequency followed the Poisson distribution and MN showed over-dispersion. The translocation and DC frequencies were nearly the same for each dose point. Micronuclei showed a comparatively lower frequency. The alpha/beta ratio for translocations (0.916) and DC (0.974) were comparable, whereas the value for MN (1.526) was much higher. The equal frequencies of translocations and DC observed for a given dose indicated that genomic translocation frequency estimated using a single pair of painted chromosomes provides a reliable and easy method to measure translocation frequency.

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Subjects: Nuclear Chemistry, Photochemistry, and Radiation

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