Journal Article

Regionally Diverse Cortical Pathology in Schizophrenia: Clues to the Etiology of the Disease

Lynn D. Selemon

in Schizophrenia Bulletin

Published on behalf of Maryland Psychiatric Research Center

Volume 27, issue 3, pages 349-377
Published in print January 2001 | ISSN: 0586-7614
Published online January 2001 | e-ISSN: 1745-1701 | DOI:
Regionally Diverse Cortical Pathology in Schizophrenia: Clues to the Etiology of the Disease

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Perhaps the most surprising revelation that has emerged from recent pathologic studies of schizophrenia is the marked cortical regional heterogeneity of the disease. Areal specific alterations of many parameters have been reported (e.g., neuronal density, density of γ-aminobutyric acid [GABA]-immunoreactive cells, and concentration of synapse-associated proteins and messenger ribonucleic acid [mRNA]s). In the past 5 years, as a flood of seemingly contradictory findings have been published, divergent findings often have been regarded as further evidence of the irreplicability and futility of postmortem studies. Although some discrepancies in findings may be due to methodological differences or to the study of different cohorts of patients, a growing number of laboratories are examining the same parameter(s) in multiple cortical areas in a single brain cohort and finding regionally specific abnormalities. These findings provide compelling evidence that cortical pathology in schizophrenia is nonuniform and complex. A major challenge in contemporary schizophrenia research is to make sense of the patterning of whole brain pathology in schizophrenia, as the mosaic of neuropathologic alterations may provide clues to the disease etiology.

Keywords: Postmortem; stereologic; thalamus; prefrontal; human

Journal Article.  0 words. 

Subjects: Child and Adolescent Psychiatry

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