Journal Article

Studies of Brain and Cognitive Maturation Through Childhood and Adolescence: A Strategy for Testing Neurodevelopmental Hypotheses

Beatriz Luna and John A. Sweeney

in Schizophrenia Bulletin

Published on behalf of Maryland Psychiatric Research Center

Volume 27, issue 3, pages 443-455
Published in print January 2001 | ISSN: 0586-7614
Published online January 2001 | e-ISSN: 1745-1701 | DOI: http://dx.doi.org/10.1093/oxfordjournals.schbul.a006886
Studies of Brain and Cognitive Maturation Through Childhood and Adolescence: A Strategy for Testing Neurodevelopmental Hypotheses

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Although neurodevelopmental models of schizophrenia are now widely accepted, there is minimal direct human evidence of dysmaturation in schizophrenia to support this theory. This is especially the case regarding maturational changes during late childhood and adolescence, which immediately precede the typical age of onset of the disorder. By integrating new noninvasive methods of functional magnetic resonance imaging with techniques of developmental cognitive neuroscience, it is now possible to begin systematic research programs to directly test hypotheses of neurodevelopmental abnormalities in schizophrenia. In this article, we describe strategies for characterizing developmental changes taking place during the critical period of adolescence that can elucidate dysmaturation processes in schizophrenia. We emphasize the need for studies characterizing normal development before examining at-risk or clinical populations, and the potential value of using neurobehavioral and neuroimaging approaches to directly characterize the dysmaturation associated with schizophrenia.

Keywords: spatial working memory; inhibition; eye movements; cerebellum; neuroimaging; prefrontal cortex

Journal Article.  0 words. 

Subjects: Child and Adolescent Psychiatry

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