Journal Article

Neurodevelopmental Origins of Tardivelike Dyskinesia in Schizophrenia Patients and Their Siblings

Baher Ismail, Elizabeth Cantor-Graae and Thomas F. McNeil

in Schizophrenia Bulletin

Published on behalf of Maryland Psychiatric Research Center

Volume 27, issue 4, pages 629-642
Published in print January 2001 | ISSN: 0586-7614
Published online January 2001 | e-ISSN: 1745-1701 | DOI:
Neurodevelopmental Origins of Tardivelike Dyskinesia in Schizophrenia Patients and Their Siblings

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The question of whether dyskinesia of the type found in tardive dyskinesia (TD) related to schizophrenia has a neurodevelopmental background was studied in a sample of 60 younger schizophrenia patients (mean age 38 years) and 21 of their non-ill siblings. TD-like dyskinesia was studied in relation to selected risk factors in the patients, and to neurological abnormality and parkinsonism in both patients and siblings. One or more signs of TD-like dyskinesia in patients were predicted by male gender, a history of obstetric complications, shorter illness duration, and shorter neuroleptic exposure. One or more signs of TD-like dyskinesia were found in 28.5 percent of the siblings and tended to be associated with neurological abnormality. Little co-occurrence of TD-like dyskinesia was found in the sibling and the patient in the same family. Patients' TD-like dyskinesia was significantly associated with hard neurological signs (independent of involuntary movements) but not with soft signs or primitive reflexes per se. TD-like dyskinesia showed a significant positive relationship to parkinsonism in patients. TD-like dyskinesia in younger schizophrenia patients appears to have neurodevelopmental antecedents and seems to represent one aspect of the total neurological abnormality associated with schizophrenia.

Keywords: Schizophrenia; tardive dyskinesia; obstetric complications; neurodevelopment; parkinsonism; neuroleptics

Journal Article.  0 words. 

Subjects: Child and Adolescent Psychiatry

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