Journal Article

Premorbid Adjustment and Neuropsychological Performance in Schizophrenia

Marshall L. Silverstein, George Mavrolefteros and David Close

in Schizophrenia Bulletin

Published on behalf of Maryland Psychiatric Research Center

Volume 28, issue 1, pages 157-165
Published in print January 2002 | ISSN: 0586-7614
Published online January 2002 | e-ISSN: 1745-1701 | DOI: http://dx.doi.org/10.1093/oxfordjournals.schbul.a006918
Premorbid Adjustment and Neuropsychological Performance in Schizophrenia

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To examine the relationship between premorbid adjustment and neuropsychological deficit in schizophrenia, this report examined retrospective ratings of social and school adjustment during three age epochs (childhood, early adolescence, and late adolescence) as predictors of neurocognitive performance in 61 clinically and pharmacologically stabilized schizophrenia outpatients. Results indicated greater cognitive deficits when premorbid adjustment was unfavorable, particularly for measures of attention and executive functions. Premorbid number and quality of peer relationships and psychosocial adaptation to the school environment were more closely related to neuropsychological performance during adulthood than were premorbid withdrawal and premorbid academic performance. Early onset of poor premorbid adjustment rather than deterioration from childhood to adolescence was associated with greater neuropsychological disturbance in adulthood. It is suggested that childhood onset of premorbid deficits in selective areas of social and academic adjustment appears to influence the cognitive performance seen in adult schizophrenia. This study is consistent with findings from other related reports; it extends these findings to a larger and clinically stabilized sample.

Keywords: Neuropsychology; social functioning; premorbid adjustment

Journal Article.  0 words. 

Subjects: Child and Adolescent Psychiatry

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