Journal Article

Prefrontal Structural and Functional Deficits in Schizotypal Personality Disorder

Adrian Raine, Todd Lencz, Pauline Yaralian, Susan Bihrle, Lori LaCasse, Joseph Ventura and Patrick Colletti

in Schizophrenia Bulletin

Published on behalf of Maryland Psychiatric Research Center

Volume 28, issue 3, pages 501-513
Published in print January 2002 | ISSN: 0586-7614
Published online January 2002 | e-ISSN: 1745-1701 | DOI:
Prefrontal Structural and Functional Deficits in Schizotypal Personality Disorder

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Structural prefrontal deficits have been reported in patients with schizophrenia, but it is unclear if they are also found in patients with schizophrenia spectrum personality disorders. The hypothesis that a spectrum group will be characterized by prefrontal structural deficits was tested by assessing prefrontal gray and white volumes using magnetic resonance imaging in a community sample of 16 individuals with schizotypal/paranoid personality disorder, 27 comparisons, and 26 psychiatric controls. Frontal neurocognitive functioning was also assessed using the Wisconsin Card Sorting Test and the Continuous Performance Test. The spectrum group showed reduced prefrontal gray volumes and poorer frontal functioning compared to both other groups. Structural deficits were independent of functional deficits and together correctly classified 84.2 percent of subjects. Structural but not functional deficits were abolished after a strict control for antisocial personality was made. Results support the notion that frontal deficits may be centrally involved in the etiology of schizophrenia but also suggest that comorbid antisocial behavior may be one factor accounting for differences in prefrontal structural findings across studies.

Keywords: Schizotypal; paranoid; prefrontal gray; MRI; antisocial

Journal Article.  0 words. 

Subjects: Child and Adolescent Psychiatry

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