Journal Article

A Candidate Molecule Approach to Defining Developmental Pathology in Schizophrenia

Cynthia Shannon Weickert and Daniel R. Weinberger

in Schizophrenia Bulletin

Published on behalf of Maryland Psychiatric Research Center

Volume 24, issue 2, pages 303-316
Published in print January 1998 | ISSN: 0586-7614
Published online January 1998 | e-ISSN: 1745-1701 | DOI: http://dx.doi.org/10.1093/oxfordjournals.schbul.a033327
A Candidate Molecule Approach to Defining Developmental Pathology in Schizophrenia

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The evidence that schizophrenia may have its origins from early in life, possibly during prenatal brain development, is based primarily on a constellation of nonspecific anatomical findings and on the results of surveys of obstetrical complications and of childhood neurological and psychological adjustment. The developmental processes implicated by this evidence are uncertain, but speculation has centered around abnormalities of neuronal proliferation, migration, and connection formation. These developmental milestones are the results of complicated cellular processes involving molecular interactions between cells and between the extracellular and intracellular milieus. To understand how these abnormalities could relate to schizophrenia, it is necessary to characterize the molecular events that define the processes. In this article, we discuss the potential impact of a number of molecules that are important in the sequence of cellular events implicated in schizophrenia. In particular, we focus on molecular mechanisms related to cell proliferation, axonal outgrowth, cell migration, cell survival, synaptic regression, myelination, and developmental aspects of early adult life. These various candidate molecules regulate different aspects of cell growth and cell-cell interactions and are involved in the regulation of deoxyribonucleic acid (DNA) expression. Very few of these molecules have been studied in the schizophrenic brain.

Keywords: Puberty; hormone receptors; growth factors; myelination

Journal Article.  0 words. 

Subjects: Child and Adolescent Psychiatry

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