Journal Article

Laterality in Functional Brain Imaging Studies of Schizophrenia

Raquel E. Gur and Samuel Chin

in Schizophrenia Bulletin

Published on behalf of Maryland Psychiatric Research Center

Volume 25, issue 1, pages 141-156
Published in print January 1999 | ISSN: 0586-7614
Published online January 1999 | e-ISSN: 1745-1701 | DOI: http://dx.doi.org/10.1093/oxfordjournals.schbul.a033361
Laterality in Functional Brain Imaging Studies of Schizophrenia

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Brain laterality in schizophrenia has been examined through the application of functional neuroimaging methods. These methods have included the 133Xenon technique for measuring cerebral blood flow (CBF); positron emission tomography for assessing rates of glucose metabolism, CBF, and neuroreceptor functioning; single photon emission computerized tomography for studying CBF and neuroreceptors; and functional magnetic resonance imaging for measuring changes attributable to CBF. This article highlights the application of this technology in schizophrenia research, emphasizing more recent studies that have evaluated hemispheric differences. There is evidence for lateralized abnormalities in some studies that have examined this dimension. In general, the results implicate abnormalities in left hemispheric activity. Recent advances in basic and clinical neuroscience provide an opportunity for focused application of functional imaging in neurobiological studies of schizophrenia.

Keywords: Laterality; hemispheric activity; functional brain imaging

Journal Article.  0 words. 

Subjects: Child and Adolescent Psychiatry

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