Journal Article

Altered Parallel Auditory Processing in Schizophrenia Patients

Eero Pekkonen, Minna Huotilainen, Heikki Katila, Jari Karhu, Risto Näätänen and Jari Tühonen

in Schizophrenia Bulletin

Published on behalf of Maryland Psychiatric Research Center

Volume 25, issue 3, pages 601-607
Published in print January 1999 | ISSN: 0586-7614
Published online January 1999 | e-ISSN: 1745-1701 | DOI:
Altered Parallel Auditory Processing in Schizophrenia Patients

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Patients with schizophrenia have impaired auditory processing that has been demonstrated by diminished P50 response to paired auditory stimuli in event-related potential (ERP) studies. Cerebral processing can also be studied with magnetoencephalography (MEG). With a whole-head MEG, which enables one to simultaneously measure brain activity in both hemispheres, we investigated whether early parallel auditory processing is impaired in schizophrenia. Sequences of tones were monaurally presented to schizophrenia patients and healthy controls in a passive condition, and the event-related magnetic fields were recorded simultaneously over both auditory cortices. The interhemispheric latency difference of the P50m, but not that of the N100m, was significantly shorter in the patient group in the right-ear but not in the left-ear stimulus condition. Further, the ipsilateral P50m was significantly earlier in schizophrenia patients in the right-ear condition. This result suggests that schizophrenia affects the consecutive preconscious auditory processing in a different manner.

Keywords: Magnetoencephalography; event-related potentials; P50; N100; schizophrenia

Journal Article.  0 words. 

Subjects: Child and Adolescent Psychiatry

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