Journal Article

Genetic Variants of Dopamine Receptor D4 and Psychopathology

Alessandro Serretti, Fabio Macciardi, Marco Catalano, Laura Bellodi and Enrico Smeraldi

in Schizophrenia Bulletin

Published on behalf of Maryland Psychiatric Research Center

Volume 25, issue 3, pages 609-618
Published in print January 1999 | ISSN: 0586-7614
Published online January 1999 | e-ISSN: 1745-1701 | DOI: http://dx.doi.org/10.1093/oxfordjournals.schbul.a033405
Genetic Variants of Dopamine Receptor D4 and Psychopathology

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There is much evidence to indicate that the dopamine receptor D4 (DRD4) gene is involved in psychiatric disorders. We investigated the correlation between DRD4 gene polymorphism and the psychopathology of major psychoses, independently of diagnoses. Some 461 inpatients affected by major psychoses were assessed by the Operational Criteria checklist for psychotic illness and typed for DRD4 variants. The four symptomatologic factors—mania, depression, delusion, and disorganization—were used as phenotype definitions. DRD4 Exon 3 long allele variants were associated with high delusional scores, with the most significant difference between alleles 2 and 7 (p=0.004). DRD4 variants may, therefore, constitute a liability factor for development of delusional symptomatology in patients with major psychoses.

Keywords: Psychopathology; DRD4; psychiatric genetics; mood disorders; schizophrenia

Journal Article.  0 words. 

Subjects: Child and Adolescent Psychiatry

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