Journal Article

Tardive Dyskinesia: Possible Involvement of Free Radicals and Treatment With Vitamin E

Ahmed M. Elkashef and Richard Jed Wyatt

in Schizophrenia Bulletin

Published on behalf of Maryland Psychiatric Research Center

Volume 25, issue 4, pages 731-740
Published in print January 1999 | ISSN: 0586-7614
Published online January 1999 | e-ISSN: 1745-1701 | DOI: http://dx.doi.org/10.1093/oxfordjournals.schbul.a033414
Tardive Dyskinesia: Possible Involvement of Free Radicals and Treatment With Vitamin E

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A decade ago a hypothesis introduced to explain tardive dyskinesia (TD) implicated free radicals generated secondary to neuroleptic treatment. Since then many preclinical and clinical studies have investigated this possibility. These studies suggest that free radicals are probably involved in the pathogenesis of TD and that vitamin E could be efficacious in its treatment.

Keywords: Tardive dyskinesia; free radicals; neurodegeneration; vitamin E; antioxidants; neuroleptic

Journal Article.  0 words. 

Subjects: Child and Adolescent Psychiatry

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