Journal Article

Neurocognitive Deficits and Functional Outcome in Schizophrenia: Are We Measuring the “Right Stuff”?

Michael Foster Green, Robert S. Kern, David L. Braff and Jim Mintz

in Schizophrenia Bulletin

Published on behalf of Maryland Psychiatric Research Center

Volume 26, issue 1, pages 119-136
Published in print January 2000 | ISSN: 0586-7614
Published online January 2000 | e-ISSN: 1745-1701 | DOI: http://dx.doi.org/10.1093/oxfordjournals.schbul.a033430
Neurocognitive Deficits and Functional Outcome in Schizophrenia: Are We Measuring the “Right Stuff”?

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There has been a surge of interest in the functional consequences of neurocognitive deficits in schizophrenia. The published literature in this area has doubled in the last few years. In this paper, we will attempt to confirm the conclusions from a previous review that certain neurocognitive domains (secondary verbal memory, immediate memory, executive functioning as measured by card sorting, and vigilance) are associated with functional outcome. In addition to surveying the number of replicated findings and tallying box scores of results, we will approach the review of the studies in a more thorough and empirical manner by applying a meta-analysis. Lastly, we will discuss what we see as a key limitation of this literature, specifically, the relatively narrow selection of predictor measures. This limitation has constrained identification of mediating variables that may explain the mechanisms for these relationships.

Keywords: Schizophrenia; neurocognition; functional outcome; social cognition; learning potential

Journal Article.  0 words. 

Subjects: Child and Adolescent Psychiatry

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