Journal Article

The Design of the Prenatal Determinants of Schizophrenia Study

Ezra S. Susser, Catherine A. Schaefer, Alan S. Brown, Melissa D. Begg and Richard Jed Wyatt

in Schizophrenia Bulletin

Published on behalf of Maryland Psychiatric Research Center

Volume 26, issue 2, pages 257-273
Published in print January 2000 | ISSN: 0586-7614
Published online January 2000 | e-ISSN: 1745-1701 | DOI:
The Design of the Prenatal Determinants of Schizophrenia Study

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This paper describes the Prenatal Determinants of Schizophrenia (PDS) Study; three companion papers report the first results. The PDS Study was designed to study early antecedents of schizophrenia in a birth cohort of 1959–1967 for whom a wealth of archived prenatal data—including maternal sera—was available. Making use of the registries of a health plan into which the cohort was born, we ascertained and then diagnosed 71 cases of schizophrenia and spectrum disorders in the cohort. We describe herein the available prenatal data, the process of case diagnosis, and the strategies used to analyze prenatal determinants of schizophrenia in this cohort. Data are presented that bear on the main sources of potential bias and are important to understanding the strengths and limitations of this unique data set.

Keywords: Schizophrenia; epidemiology; prenatal

Journal Article.  0 words. 

Subjects: Child and Adolescent Psychiatry

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