Journal Article

Pitfalls of Multisite Randomized Clinical Trials of Efficacy and Effectiveness

Helena Chmura Kraemer

in Schizophrenia Bulletin

Published on behalf of Maryland Psychiatric Research Center

Volume 26, issue 3, pages 533-541
Published in print January 2000 | ISSN: 0586-7614
Published online January 2000 | e-ISSN: 1745-1701 | DOI: http://dx.doi.org/10.1093/oxfordjournals.schbul.a033474
Pitfalls of Multisite Randomized Clinical Trials of Efficacy and Effectiveness

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This article discusses common pitfalls of multisite randomized clinical trials of efficacy and effectiveness. Issues considered include (1) premature initiation, (2) ineffective study structure, (3) too much or too little communication among researchers, (4) neglect of site differences, (5) use of “naked” p values, (6) premature closure, and (7) overreliance on the interpretation and memory of individual researchers. If future researchers are aware of these common pitfalls, they may be able to avoid them.

Keywords: Multisite studies; randomized clinical trials; research planning; research organization

Journal Article.  0 words. 

Subjects: Child and Adolescent Psychiatry

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